Donnerstag, 6. Oktober 2016 | 13:15 - 14:15 Uhr | RWE Pavillon
Vorsitz: Lutz Renders (München, DE), Claudia Sommerer (Heidelberg, DE)
13:15 V004 |
Frailty und kardiovaskuläre Status – Ab wann Kontraindikation zur Nierentransplantation? Ute Eisenberger Universitätsklinikum Essen, Klinik für Nephrologie, Essen, DE |
13:30 V005 |
Immunologische Aspekte vs. Organqualität bei der Organakzeptanz Martina Koch Universitätsklinikum Hamburg-Eppendorf, Klinik und Poliklinik für Hepatobiliäre Chirurgie und Transplantationschirurgie, Hamburg, DE |
13:45 V006 |
Mangelernährung auf der Warteliste Mirian Opgenoorth Universitätsklinikum Carl Gustav Carus, Medizinische Klinik III - Bereich Nephrologie, Dresden, DE |
14:00 V007 |
Presensitization with alloreactive T-cells predicts outcome in kidney transplant recipients Abstract T. Schachtner , P. Reinke Charité CVK Nephrologie, Berlin, DE Einleitung und Fragestellung / Introduction and Background Alloreactive T-cells have been suggested to impact allograft outcome due to a higher incidence of acute cellular rejection. Knowledge on risk factors for the development of preformed and de-novo alloreactive T-cells, however, remains scarce. Methodik / Methods We analyzed 327 primary kidney transplant recipients (KTRs) transplanted from 2008 to 2014. KTRs were grouped regarding the pretransplant alloreactive T-cells. KTRs without pretransplant alloreactive T-cells were grouped regarding the development of de-novo alloreactive T-cells. Samples were collected pretransplantation, at +1, +2, +3 months posttransplantation, and alloreactive T-cells were measured by interferon-γ Elispot assay. Ergebnisse und Schlussfolgerungen / Results and Conclusions Among 327 KTRs, 107 KTRs (33%) showed pretransplant alloreactive T-cells. Risk factors for the presence of preformed alloreactive T-cells included older age, diabetes, and prior malignancies (p<0.05). Preformed alloreactive T-cells were associated with a higher incidence of delayed graft function (p=0.017). Among 220 KTRs without alloreactive T-cells pretransplantation, 31 KTRs (14%) showed de-novo alloreactive T-cells. Risk factors included female sex and prior malignancies (p<0.05). KTRs with preformed/de-novo alloreactive T-cells showed inferior patient survival, allograft survival, and allograft function, a higher incidence of acute cellular rejections, sepsis, and posttransplant malignancies (p<0.05). The presence of alloreactive T-cells strongly impacts patient and allograft outcomes. Insulin therapy, and treated or undetected malignancies may lead to presensitization with preformed alloreactive T-cells. Caution should be taken in KTRs with alloreactive T-cells with regards to minimizing immunosuppression. |
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Deutsche Transplantationsgesellschaft e.V.
DTG Geschäftsstelle
Frau Marion Schlauderer
Universitätsklinikum Regensburg
Abteilung für Nephrologie
Franz-Josef-Strauß-Allee 11
93053 Regensburg
+49 941 9447324
+49 941 9447197
dtg.sekretariat@ukr.de